There are various classes of men. One class is called akāmīs, referring to those who have no material desire. Desire must exist, either material or spiritual. Material desire arises when one wants to satisfy one's personal senses. One who is ready to sacrifice anything to satisfy the Supreme Personality of Godhead can be said to have spiritual desire. Dhruva did not accept the instruction given by the great saint Nārada because he thought himself unfit for such instruction, which prohibited all material desires. It is not a fact, however, that those who have material desires are prohibited from worshiping the Supreme Personality of Godhead. This is the essential instruction from the life of Dhruva. He frankly admitted that his heart was full of material desires. He was very much affected by the cruel words of his stepmother, whereas those who are spiritually advanced do not care about anyone's condemnation or adoration.
(Srimad Bhagavatam--4:8:35--purport).

As stated in Śrīmad-Bhāgavatam, kāmaṁ hṛd-rogam. Materialistic life means that one is afflicted by a formidable disease called lusty desire. Liberation means freedom from lusty desires because it is only due to such desires that one must accept repeated birth and death. As long as one's lusty desires are unfulfilled, one must take birth after birth to fulfill them. Because of material desires, therefore, one performs various types of activities and receives various types of bodies with which to try to fulfill desires that are never satisfied. The only remedy is to take to devotional service, which begins when one is free from all material desires. Anyābhilāṣitā-śūnyam (Bhakti-rasāmṛta-sindhu 1.1.11). Anya-abhilāṣitā means "material desire," and śūnyam means "free from." The spiritual soul has spiritual activities and spiritual desires, as described by Śrī Caitanya Mahāprabhu: mama janmani janmanīśvare bhavatād bhaktir ahaitukī tvayi (Cc. Antya 20.29, Śikṣāṣṭaka 4). Unalloyed devotion to the service of the Lord is the only spiritual desire. To fulfill this spiritual desire, however, one must be free from all material desires. Desirelessness means freedom from material desires. This is described by Śrīla Rūpa Gosvāmī as Anyābhilāṣitā-śūnyam (Bhakti-rasāmṛta-sindhu 1.1.11). As soon as one has material desires, one loses his spiritual identity. Then all the paraphernalia of one's life, including one's senses, body, religion, patience and intelligence, are deviated from one's original Kṛṣṇa consciousness. As soon as one has material desires, one cannot properly use his senses, intelligence, mind and so on for the satisfaction of the Supreme Personality of Godhead.
(Srimad Bhagavatam---7:10:8--purport).

Whatever is attractive within the cosmic manifestation is due to Kṛṣṇa. Kṛṣṇa is therefore the reservoir of all pleasure. The active principle of everything is Kṛṣṇa, and highly elevated transcendentalists see everything in connection with Him. In the Caitanya-caritāmṛta it is stated that a mahā-bhāgavata, or highly advanced devotee, sees Kṛṣṇa as the active principle in all movable and immovable living entities. Therefore he sees everything within this cosmic manifestation in relation to Kṛṣṇa. For the fortunate person who has taken shelter of Kṛṣṇa as everything, liberation is already there. He is no longer in the material world. This is confirmed in the Bhagavad-gītā: Whoever is engaged in the devotional service of Kṛṣṇa is already on the brahma-bhūta, (S.B.4:30:20) or spiritual, platform. The very name Kṛṣṇa suggests piety and liberation. Anyone who takes shelter of the lotus feet of Kṛṣṇa enters the boat for crossing over the ocean of nescience. For him, this vast expanse of the material manifestation becomes as insignificant as the water in a calf's hoofprint. Kṛṣṇa is the shelter of all great souls, and He is also the shelter of the material worlds. For one who is on the platform of Kṛṣṇa consciousness, Vaikuṇṭha, or the spiritual world, is not far away. He does not live within the material world, where there is danger at every step.

In this way, Kṛṣṇa consciousness was fully explained to Mahārāja Parīkṣit by Śukadeva Gosvāmī as he recited to the King the statements and prayers of Lord Brahmā. These descriptions of Lord Kṛṣṇa's pastimes with His cowherd boys, His eating with them on the bank of the Yamunā, and Lord Brahma's prayers unto Him are all transcendental subject matters. Anyone who hears, recites or chants them surely gets all his spiritual desires fulfilled. Thus Kṛṣṇa's childhood pastimes, His sporting with Balarāma and the cowherd boys in Vṛndāvana, were described.
(Krsna Book).