Here is the remedy for eliminating all inauspicious things within the heart which are considered to be obstacles in the path of self-realization. The remedy is the association of the Bhāgavatas. There are two types of Bhāgavatas, namely the book Bhāgavata and the devotee Bhāgavata. Both the Bhāgavatas are competent remedies, and both of them or either of them can be good enough to eliminate the obstacles. A devotee Bhāgavata is as good as the book Bhāgavata because the devotee Bhāgavata leads his life in terms of the book Bhāgavata and the book Bhāgavata is full of information about the Personality of Godhead and His pure devotees, who are also Bhāgavatas. Bhāgavata book and person are identical.
(Srimad Bhagavatam-----1:2:18-----purport).

Initially, one must develop confidence by hearing the science of devotion from a qualified spiritual master. Then, as he associates with devotees and tries to adopt the means instructed by the spiritual master in his own life, his misgivings and other obstacles are vanquished by his execution of devotional service. Strong attachment for the transcendental service of the Lord develops as he continues listening to the messages of Godhead, and if he steadfastly proceeds in this way, he is certainly elevated to spontaneous love for the Supreme Personality of Godhead.
(Sri Caitanya Caritamrta-----1:1:60-----purport).

There are sometimes pseudodevotees, and one should be very much cautious about them. There are many things which hinder one from entering devotional service. But by the association of pure devotees all these obstacles are removed. The neophyte devotee becomes practically enriched with the transcendental qualities of the pure devotee, which means attraction for the Personality of Godhead's name, fame, quality, pastimes, etc. Infection of the qualities of the pure devotee means to imbibe the taste of pure devotion always in the transcendental activities of the Personality of Godhead. This transcendental taste at once makes all material things distasteful. Therefore a pure devotee is not at all attracted by material activities. After the elimination of all sins or obstacles on the path of devotional service, one can become attracted, one can have steadiness, one can have perfect taste, one can have transcendental emotions, and at last one can be situated on the plane of loving service of the Lord.
(Srimad Bhagavatam-----1:5:25-----purport).

There are many religious propagandists who do not know how the ultimate problems of life can be solved, and they also try to educate people in a form of sense gratification. This is also jīva-hiṁsana. Real knowledge is not given, and religionists mislead the general populace. As far as material profits are concerned, one should know that whatever material profit one has must be abandoned at the time of death. Unfortunately people do not know that there is life after death; therefore mundane people waste their time amassing material profit which has to be left behind at the time of death. Such profit has no eternal benefit. Similarly, adoration by mundane people is valueless because after death one has to accept another body. Material adoration and titles are decorations that cannot be carried over to the next body. In the next life, everything is forgotten. All these obstructions have been described in this verse as unwanted creepers. They simply present obstacles for the real creeper, the bhakti-latā. One should be very careful to avoid all these unwanted things. Sometimes these unwanted creepers look exactly like the bhakti creeper. They appear to be of the same size and the same species when they are packed together with the bhakti creeper, but in spite of this, the creepers are called upaśākhā. A pure devotee can distinguish between the bhakti creeper and a mundane creeper, and he is very alert to distinguish them and keep them separate.
(Sri Caitanya Caritamrta-----2:19:159-----purport).

The whole world is struggling very hard to exist out of these miseries, but men do not know that without the sanction of the Lord no plan or no remedial measure can actually bring about the desired peace and tranquillity. The remedial measure to cure a patient by medical treatment is useless if it is not sanctioned by the Lord. To cross the river or the ocean by a suitable boat is no remedial measure if it is not sanctioned by the Lord. We should know for certain that the Lord is the ultimate sanctioning officer, and we must therefore dedicate our attempts to the mercy of the Lord for ultimate success or to get rid of the obstacles on the path of success.
(Srimad Bhagavatam-----1:5:32-----purport).

One deviates from the path of yoga because of forgetfulness. In devotional service there is no such apprehension, because the Supreme Lord always protects the bhakti-yogī. Even if the bhakti-yogī falls down, he can regain his former position by receiving strength from the Lord. Because of his remembrance of the Lord, all obstacles on his path are cleared away. Therefore the process of surrender leads to real perfection in yoga; it is the easiest path to follow and is also the most direct.
(Renunciation through Wisdom).

The word hari conveys various meanings, but the chief import of the word is that He (the Lord) vanquishes everything inauspicious and takes away the mind of the devotee by awarding pure transcendental love. By remembering the Lord in acute distress one can be free from all varieties of miseries and anxieties. Gradually the Lord vanquishes all obstacles on the path of devotional service of a pure devotee, and the result of nine devotional activities, such as hearing and chanting, becomes manifested.
(Srimad Bhagavatam-----1:7:10-----purport).

A conditioned soul does not know what complete independence is. Complete independence means situation in one's own constitutional position. The real independence of a living entity, who is part and parcel of the Supreme Personality of Godhead, is to remain always dependent on the Supreme Lord, just like a child who plays in complete independence, guided by his parents, who watch over him. The independence of the conditioned soul does not mean to fight with the obstacles offered by māyā, but to surrender to Kṛṣṇa. In the material world, everyone is trying to become completely independent simply by fighting against the obstacles offered by māyā. This is called the struggle for existence. Real independence is to be reinstated in the service of the Lord. Anyone who goes to the Vaikuṇṭha planets or Goloka Vṛndāvana planet is freely offering his service to the Lord. That is complete independence.
(Srimad Bhagavatam-----4:9:35-----purport).

The Lord always resides in the heart of His pure devotees, and so they have the potency to purify the places of pilgrimage, which become heavily laden with the sins deposited there by all the pilgrims. These are some of the glories of the Lord's pure, surrendered devotees. Lord Kṛṣṇa says In the Bhagavad-gītā (18.58), mac-cittaḥ sarva-durgāṇi mat-prasādāt tariṣyasi: "If you become conscious of Me, you will pass over all the obstacles of conditioned life by My grace." Therefore fruitive activity, the search for empirical knowledge, and mystic yoga all culminate in surrender to the Supreme Lord.
(Renunciation through Wisdom).

One has to accept a bona fide spiritual master and work according to his direction. Then it is possible to cross over the nescience of material conditions. Śrīpāda Śrīdhara Svāmī has composed a nice verse in this connection, in which he says, “O all-merciful spiritual master, representative of the Supreme Personality of Godhead, when my mind will be completely surrendered unto your lotus feet, at that time, only by your mercy, I shall be able to get relief from all obstacles to spiritual life, and I shall be situated in blissful life.”
(Krsna Book).