In the Vedas it is said that persons who are attached to demigods to the exclusion of the Supreme Personality of Godhead are like the animals who follow the herdsman even though they are taken to the slaughterhouse. The materialists, like animals, also do not know how they are being misdirected by neglecting the transcendental thought of the Supreme person. No one can remain vacant of thought. It is said that an idle brain is a devil's workshop because a person who cannot think in the right way must think of something which may bring about disaster. The materialists are always worshiping some minor demigods, although this is condemned in the Bhagavad-gītā (7.20). As long as a person is illusioned by material gains, he petitions the respective demigods to draw some particular benefit which is, after all, illusory and nonpermanent. The enlightened transcendentalist is not captivated by such illusory things; therefore he is always absorbed in the transcendental thought of the Supreme in different stages of realization, namely Brahman, Paramātmā and Bhagavān. In the previous verse it is suggested that one should think of the Supersoul, which is one step higher than the impersonal thought of Brahman, as it was suggested in the case of contemplating the virāṭ-rūpa of the Personality of Godhead.
(Srimad Bhagavatam--2;2:7--purport).

They stress on knowledge. What is this knowledge? You can talk on any insignificant thing for many years. That is not knowledge. Just like in the present modern civlization, so many nonsense articles without any utility, or volumes of volumes of books are sold in the market. There is nothing, no substance. Take for this..., newspaper. Especially in your country, volumes of papers in the news. Just after glancing over, it is thrown away. That's all. No more use. Just as The newspaper is published early in the morning, and just in the afternoon it is useless, it is heap of paper only, because there is no substance. Nobody can take any interest. But see Bhagavad-gītā, it is, five thousand years before it was published, and a few pages only, and how much care is being taken after Bhagavad-gītā. Because there is substance. Similarly, if you don't accept the substance, simply if you are busy with the skin... In Bengali it is called cavara nie tanake (?). Cavara means skin. You have seen coconut. The coconut is covered by heavy, what is called,fibers. So if you give up the coconut and simply quarrel with the fibers, what profit is there? There is no profit. Similarly, if you give up God, or Kṛṣṇa, who is the essence of everything, and you make your advancement in scientific knowledge, in physics and chemistry and so many departments of knowledge, so according to Bhāgavata this is simply waste of time. Simply waste of time. But what we'll gain? Kevala-bodha-labdhaye. Suppose you understand in your human form of life the whole constitution of the universe... That is stated in Bible also, that "If somebody understands everything, but not God, then what does he gain?"
(Lecture on Sri Caitanya Caritamrta--2:25:19-31--San francisco--20th. January, 1967).

The Lord is the constant companion of the living entity as Paramātmā, or the Supersoul, and therefore He can understand the desires of the individual soul, as one can smell the flavor of a flower by being near it. Desire is a subtle form of conditioning for the living entity. The Lord fulfills his desire as he deserves: Man proposes and God disposes. The individual is not, therefore, omnipotent in fulfilling his desires. The Lord, however, can fulfill all desires, and the Lord, being neutral to everyone, does not interfere with the desires of the minute independent living entities. However, when one desires Kṛṣṇa, the Lord takes special care and encourages one to desire in such a way that one can attain to Him and be eternally happy.
(Bhagavad-Gita--5:15--purport).